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KMID : 0381920110410010001
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Korean Journal of Microscopy
2011 Volume.41 No. 1 p.1 ~ p.11
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Ultrastructural Alterations in the Gastric Mucous Epithelial Cells of Mouse Inoculated with Ehrlich Carcinoma Cells, Induced by 5-Fluorouracil, Mitomycin C or Acriflavine-Guanosine Compound (AG60)
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Ko Eun-Ju
Park Kyung-Ho
Park Dae-Kyun
Kim Duk-Soo
Ko Jeong-Sik
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Abstract
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This experiment was performed to evaluate the morphological responses of the gastric epithelial cells of the mouse, inoculated with Ehrlich carcinoma cells in the inguinal area, following administration of 5-fluorouracil, mitomycin C or Acriflavine-Guanosine compound (AG60). In this study, each mouse was inoculated with 1×107 Ehrlich carcinoma cells subcutaneously in the inguinal area. From next day after inoculations, 0.2 mL of saline, 5-fluorouracil (30 mg/kg), mitomycin C (400 μg/kg) or AG60 (30 mg/ kg) were injected to the animals every other day, respectively. Each animals were sacrificed after 7th injection and tissue were taken from the gastric mucosa. Thereafter, the ultrathin sections were stained with uranyl acetate and lead citrate. In the 5-fluorouracil-, mitomycin C- or AG60-treated mice, myelin figures and multivesicular bodies within the gastric mucous epithelial cells were observed more frequently than those of the normal control. In the 5-fluorouracil-treated mice, membrane structures containing a few mucous granules in the luminal space were observed. Indeed, bulging cytoplasmic process containing mucous granules protruding into the gastric lumen were observed in the mitomycin Ctreated mice. Therefore, this study suggested that AG60 as compared with 5-fluorourail and mitomycin C may effective medicine without damage to the secretion ability of gastric mucous epithelial cells.
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KEYWORD
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AG60, gastric epithelial cells, 5-fluorouracil, mitomycin C, ultrastructure
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